drug_type
RELEVANT_DRUG
intervention_type
monoclonal antibody
drug_description
Anti-CD47 monoclonal antibody (immune checkpoint inhibitor) that blocks the CD47–SIRPα 'don’t‑eat‑me' signal to enhance macrophage-mediated phagocytosis of malignant myeloid cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Anti-CD47 monoclonal antibody that blocks the CD47–SIRPα checkpoint, removing the 'don’t-eat-me' signal and enhancing macrophage-mediated phagocytosis of malignant myeloid cells.
drug_name
AK117
nct_id_drug_ref
NCT06196203