drug_type
RELEVANT_DRUG
intervention_type
Biological - monoclonal antibody
drug_description
Humanized IgG1 monoclonal antibody immunotherapy targeting CSF1R; blocks CSF1R to inhibit CSF1/M-CSF signaling and depletes CSF1R+ macrophages via receptor blockade and Fc-mediated clearance, reducing macrophage-driven tumor burden in TGCT.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
emactuzumab
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Humanized IgG1 monoclonal antibody against CSF1R that blocks CSF1/M-CSF binding and downstream signaling, and engages Fc effector functions to deplete CSF1R+ macrophages (e.g., tumor-associated macrophages/giant cells), thereby reducing macrophage-driven pathology in TGCT.
drug_name
Emactuzumab (RG7155)
nct_id_drug_ref
NCT05417789