drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
Humanized anti-HER2 antibody–drug conjugate that binds HER2 and delivers the microtubule-disrupting payload MMAE, causing cell-cycle arrest and apoptosis; may also mediate ADCC.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Disitamab Vedotin
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Humanized anti-HER2 antibody–drug conjugate that binds HER2 on tumor cells, is internalized, and releases the microtubule-disrupting payload MMAE to induce G2/M cell-cycle arrest and apoptosis; may additionally mediate antibody-dependent cellular cytotoxicity (ADCC).
drug_name
Disitamab vedotin (RC48; vedicitumomab/Edisil)
nct_id_drug_ref
NCT05898373