Autologous γδ T cells are genetically engineered to express a third‑generation chimeric antigen receptor that binds mesothelin. Antigen engagement delivers CD3ζ signaling with co‑stimulation, activating the γδ T cells to proliferate, secrete cytotoxic molecules and cytokines, and lyse mesothelin‑expressing tumor cells in an MHC‑independent manner while leveraging innate γδ T cell tumor‑targeting properties.