drug_type
RELEVANT_DRUG
intervention_type
Small-molecule chemotherapeutic
drug_description
Microtubule dynamics inhibitor payload released from MORAb-202 inside FRα-expressing cells, causing G2/M arrest and apoptosis.
nci_thesaurus_concept_id
C96748
nci_thesaurus_definition
An analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression.
drug_mesh_term
Eribulin
drug_category
CHEMOTHERAPY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Eribulin is a halichondrin B analogue that binds to the vinca domain of tubulin and inhibits microtubule polymerization, disrupting mitotic spindle formation and causing G2/M cell-cycle arrest and apoptosis. In MORAb-202, eribulin is the cytotoxic payload released intracellularly after FRα-mediated endocytosis.
drug_name
Eribulin
nct_id_drug_ref
NCT05613088