drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
Bispecific IgG1 monoclonal antibody targeting EGFR and LGR5; inhibits EGFR signaling, promotes receptor internalization, and mediates ADCC to eliminate EGFR+/LGR5+ HNSCC cells, including stem-like cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Bispecific
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Bispecific IgG1 monoclonal antibody that binds EGFR and LGR5 on tumor cells to block EGFR signaling, promote receptor internalization/degradation, and leverage Fc-mediated ADCC to eliminate EGFR+/LGR5+ cancer cells, including stem-like populations.
drug_name
Petosemtamab (MCLA-158)
nct_id_drug_ref
NCT06496178