drug_type
RELEVANT_DRUG
intervention_type
Cell therapy (CAR-NK)
drug_description
Allogeneic cord blood–derived natural killer cells engineered with a TROP2-specific CAR and an IL-15 transgene to provide targeted NK cytotoxicity against TROP2-positive tumor cells and enhance NK survival and persistence.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
CAR NK
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Allogeneic cord blood–derived NK cells engineered with a TROP2-specific chimeric antigen receptor to direct antigen-specific NK cytotoxicity against TROP2-positive tumor cells; co-expression of IL-15 supports NK activation, survival, proliferation, and persistence in vivo.
drug_name
TROP2-CAR-NK Cells
nct_id_drug_ref
NCT06358430