drug_type
RELEVANT_DRUG
intervention_type
Antibody-drug conjugate
drug_description
Anti-HER2 antibody–drug conjugate delivering the microtubule inhibitor DM1 to HER2-expressing cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Ado-Trastuzumab Emtansine
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Trastuzumab (anti‑HER2 mAb) conjugated to DM1, a maytansinoid microtubule inhibitor. After binding HER2 on tumor cells, the complex is internalized and DM1 is released intracellularly to disrupt microtubules, causing cell-cycle arrest and apoptosis; trastuzumab also inhibits HER2 signaling and can mediate ADCC.
drug_name
Ado-trastuzumab emtansine (T-DM1)
nct_id_drug_ref
NCT06718335