drug_type
RELEVANT_DRUG
intervention_type
Cellular vaccine (autologous dendritic cell therapy)
drug_description
Cell-based cancer vaccine in which a patient's own dendritic cells are loaded with patient-specific neoantigen peptides to present via MHC I/II and prime/expand CD8+ cytotoxic and CD4+ helper T-cell responses.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Cancer Vaccines
drug_category
DC VACCINE
drug_class
Vaccine
drug_delivery_route
Subcutaneous
drug_mechanism_of_action
Autologous dendritic cells are loaded ex vivo with patient-specific neoantigen peptides and reinfused to present these antigens via MHC I/II with costimulatory signals, thereby priming and expanding tumor-specific CD8+ cytotoxic and CD4+ helper T cells to mount durable antitumor immune responses.
drug_name
Personalized neoantigen-loaded autologous dendritic cell (DC) vaccine
nct_id_drug_ref
NCT06751849