drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy/Vaccine
drug_description
Autologous TH1-polarizing dendritic cell vaccine loaded with patient tumor lysate and mRNA-encoded antigens to enhance antigen presentation (MHC I/II) and prime CD8+ cytotoxic T cells and CD4+ TH1 responses, boosting IFN-γ–mediated antitumor immunity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
RNA, Messenger
drug_category
DC VACCINE
drug_class
Vaccine
drug_delivery_route
Not specified
drug_mechanism_of_action
Autologous TH1-polarized dendritic cells are loaded ex vivo with patient tumor lysate and mRNA-encoded tumor antigens. The DCs process/translate antigens and present peptides on MHC class I and II to cross-prime tumor-specific CD8+ cytotoxic T cells and activate CD4+ TH1 cells, enhancing IFN-γ–mediated antitumor immunity.
drug_name
mRNA plus Lysate-loaded Dendritic Cell Vaccine
nct_id_drug_ref
NCT05799612