drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy
drug_description
Off-the-shelf allogeneic anti-EGFR–conjugated gamma delta T-cell therapy; healthy-donor γδ T cells conjugated to an anti-EGFR antibody to redirect cytotoxicity toward EGFR-expressing tumor cells; mediates killing via T-cell effector functions.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
OTHER ENGINEERED IMMUNE CELL
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Off-the-shelf allogeneic gamma delta (gdT) T cells chemically conjugated to an anti-EGFR antibody; the antibody directs the gdT cells to EGFR-expressing tumor cells, enabling MHC-independent recognition and T-cell effector–mediated cytotoxicity (perforin/granzyme release and cytokine production).
drug_name
ACE2016
nct_id_drug_ref
NCT06415487