drug_type
RELEVANT_DRUG
intervention_type
Antibody-drug conjugate (biologic)
drug_description
HER2-targeted antibody–drug conjugate; an anti-HER2 monoclonal antibody linked to MMAE (microtubule inhibitor) that is released after internalization to induce mitotic arrest and apoptosis, with potential ADCC/bystander effects.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibody-Drug Conjugates
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
HER2‑targeted antibody–drug conjugate: the anti‑HER2 mAb binds HER2 on tumor cells, is internalized, and releases the cytotoxic payload MMAE (microtubule inhibitor) after linker cleavage, disrupting tubulin polymerization to induce mitotic arrest and apoptosis; may also mediate ADCC and bystander killing.
drug_name
Disitamab Vedotin (RC48)
nct_id_drug_ref
NCT06734182