drug_type
RELEVANT_DRUG
intervention_type
Cellular gene therapy (TCR-engineered autologous T cells)
drug_description
Autologous, humanized MAGE-A4-directed T-cell receptor-engineered T-cell therapy. Infused T cells recognize MAGE-A4 peptides presented by HLA-A*02 on tumor cells and mediate TCR signaling, cytokine release, and cytotoxic killing.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
T-Lymphocytes, Transgenic
drug_category
ENGINEERED TCR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells are genetically engineered to express a humanized TCR that recognizes MAGE-A4 peptides presented by HLA-A*02 on tumor cells; engagement triggers TCR signaling, cytokine release, expansion, and perforin/granzyme-mediated cytotoxic killing.
drug_name
JWTCR001 (TCR-MAGE-A4 T cells)
nct_id_drug_ref
NCT06170294