drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
Recombinant SIRPα–IgG4 Fc fusion protein that binds CD47 to block the "don’t‑eat‑me" signal and enhance macrophage/monocyte phagocytosis.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
INHIBITORY FUSION PROTEIN
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Recombinant SIRPα–IgG4 Fc fusion protein that binds CD47 on tumor cells, blocking the CD47–SIRPα “don’t‑eat‑me” signal and thereby promoting macrophage/monocyte phagocytosis and innate anti-tumor activity.
drug_name
Maplirpacept (TTI-622)
nct_id_drug_ref
NCT05507541