drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
SIRPα–Fc fusion protein that binds CD47 to inhibit the "don’t‑eat‑me" signal and promote macrophage-mediated phagocytosis.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
TTI-621
drug_category
INHIBITORY FUSION PROTEIN
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Recombinant SIRPα–Fc fusion protein that binds and blocks CD47 on tumor cells, interrupting the CD47–SIRPα inhibitory checkpoint (“don’t‑eat‑me” signal) to promote macrophage/monocyte-mediated phagocytosis, aided by Fc engagement of Fcγ receptors.
drug_name
Ontorpacept (TTI-621)
nct_id_drug_ref
NCT05507541