drug_type
RELEVANT_DRUG
intervention_type
Drug (ADC)
drug_description
A humanized anti-CEACAM5 antibody-drug conjugate that binds CEACAM5 on tumor cells, is internalized, and releases the camptothecin-class topoisomerase I inhibitor payload (tocentecan), causing DNA damage and tumor cell death.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibody-Drug Conjugates
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Humanized anti-CEACAM5 antibody-drug conjugate that binds CEACAM5 on tumor cells, is internalized, and releases the camptothecin-class topoisomerase I inhibitor tocentecan, causing DNA damage and tumor cell death.
drug_name
M9140 (precemtabart tocentecan)
nct_id_drug_ref
NCT06806046