drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
TROP2-targeted antibody–drug conjugate delivering a topoisomerase I inhibitor payload to TROP2-expressing tumor cells, leading to DNA damage and tumor cell death after internalization.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Anti-TROP2 monoclonal antibody linked to a topoisomerase I inhibitor; binds TROP2 on tumor cells, is internalized, and releases the cytotoxic payload to inhibit topoisomerase I, causing DNA damage and tumor cell death.
drug_name
Sacituzumab tirumotecan (MK-2870/SKB264)
nct_id_drug_ref
NCT06170788