drug_type
RELEVANT_DRUG
intervention_type
Gene-modified cellular therapy
drug_description
Natural killer cells engineered with a chimeric antigen receptor to direct antigen-specific, MHC-independent cytotoxicity against lymphoma cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Receptors, Chimeric Antigen
drug_category
CAR NK
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Natural killer cells are engineered to express a chimeric antigen receptor that enables antigen-specific, MHC-independent recognition of lymphoma cells, triggering NK activation and cytotoxicity (perforin/granzyme release) and cytokine secretion to mediate targeted tumor cell killing.
drug_name
CAR-NK cell therapy
nct_id_drug_ref
NCT06541327