drug_type
RELEVANT_DRUG
intervention_type
Gene-modified cellular therapy
drug_description
T cells engineered to express a tumor-specific T-cell receptor, mediating peptide–HLA–restricted recognition and cytotoxicity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Receptors, Antigen, T-Cell
drug_category
ENGINEERED TCR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
T cells are genetically engineered to express a tumor-specific T-cell receptor that recognizes peptide antigens presented by specific HLA molecules; upon TCR engagement, the cells activate and mediate MHC/HLA-restricted tumor cell killing via perforin/granzyme release and cytokine-driven cytotoxicity.
drug_name
TCR-engineered T-cell (TCR-T) therapy
nct_id_drug_ref
NCT06541327