Skip to main content
drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
A subcutaneous bispecific T‑cell–engaging monoclonal antibody (Lunsumio) that binds CD20 on B cells and CD3 on T cells to recruit and activate cytotoxic T cells against malignant B cells.
nci_thesaurus_concept_id
C129691
nci_thesaurus_preferred_term
Mosunetuzumab
nci_thesaurus_definition
A bispecific, humanized monoclonal antibody with potential antineoplastic activity. Mosunetuzumab contains two antigen-recognition sites: one for human CD3, a T-cell surface antigen, and one for human CD20, a tumor-associated antigen (TAA) that is exclusively expressed on B-cells during most stages of B-cell development and is often overexpressed in B-cell malignancies. Upon administration, mosunetuzumab binds to both T-cells and CD20-expressing tumor B-cells; this cross-links T-cells to tumor cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against CD20-expressing tumor B-cells.
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Subcutaneous
drug_mechanism_of_action
Humanized bispecific monoclonal antibody that simultaneously binds CD20 on B cells and CD3 on T cells, cross-linking T cells to malignant B cells to activate cytotoxic T-lymphocyte responses (immune synapse formation, perforin/granzyme release) and kill CD20-positive tumor cells.
drug_name
Mosunetuzumab
nct_id_drug_ref
NCT06453044