drug_type
RELEVANT_DRUG
intervention_type
Cell therapy
drug_description
Allogeneic anti-CD19 chimeric antigen receptor natural killer (CAR-NK) cell therapy designed to deplete CD19+ B-lineage cells in SLE.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Natural Killer Cells
drug_category
CAR NK
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Allogeneic NK cells engineered to express an anti-CD19 chimeric antigen receptor recognize CD19 on B-lineage cells and eliminate them via NK cytotoxic mechanisms (perforin/granzyme and death receptor signaling), depleting autoreactive B cells and plasmablasts to reduce autoantibody production in SLE.
drug_name
KN5501
nct_id_drug_ref
NCT06010472