drug_type
RELEVANT_DRUG
intervention_type
cellular gene therapy (CAR-NK)
drug_description
iPSC-derived natural killer cells engineered with a chimeric antigen receptor targeting CD33 to direct NK-mediated cytotoxicity against AML cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Killer Cells, Natural
drug_category
CAR NK
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
iPSC-derived natural killer cells engineered to express a chimeric antigen receptor that binds CD33 on AML blasts, triggering antigen-specific NK activation and cytotoxicity (perforin/granzyme release and cytokine-mediated killing) to eliminate CD33-positive leukemia cells.
drug_name
CD33 CAR-NK cells
nct_id_drug_ref
NCT05987696