drug_type
RELEVANT_DRUG
intervention_type
Vaccine (Biologic)
drug_description
A patient-specific neoantigen peptide vaccine designed to elicit anti-tumor immunity by promoting dendritic cell/MHC presentation of tumor-derived neoantigens, priming and expanding tumor-specific CD8+ cytotoxic and CD4+ helper T cells and generating immune memory.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
PEPTIDE VACCINE
drug_class
Vaccine
drug_delivery_route
Not specified
drug_mechanism_of_action
Patient-specific tumor neoantigen peptides are taken up by dendritic cells and presented on MHC class I and II, priming and expanding neoantigen-specific CD8+ cytotoxic and CD4+ helper T cells to mediate tumor cell killing and establish durable immune memory.
drug_name
Personalized neoantigen vaccine
nct_id_drug_ref
NCT05153304