drug_type
RELEVANT_DRUG
intervention_type
Cellular gene therapy
drug_description
Autologous T cells genetically engineered to express a chimeric antigen receptor (CAR) that recognizes tumor antigens independently of MHC, leading to T-cell activation, cytotoxic killing of malignant hematologic cells, and cytokine release.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells are genetically engineered to express a chimeric antigen receptor that binds tumor antigens independent of MHC, triggering T‑cell activation, expansion, and cytotoxic killing of malignant hematologic cells with associated cytokine release.
drug_name
CAR T-cell therapy
nct_id_drug_ref
NCT06041815