drug_type
RELEVANT_DRUG
intervention_type
Bispecific antibody
drug_description
Off-the-shelf dual-binding antibodies (commonly CD3×CD20) that redirect T cells to kill CD20-positive B cells.
nci_thesaurus_concept_id
C1454
drug_mesh_term
Antibodies, Bispecific
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Not specified
drug_mechanism_of_action
Off‑the‑shelf bispecific antibody that simultaneously binds CD3 on T cells and CD20 on B cells, forming an immunologic synapse to activate and redirect cytotoxic T cells for MHC‑independent lysis of CD20‑positive malignant B cells via perforin/granzyme release and cytokine‑mediated killing.
drug_name
Bispecific antibody
nct_id_drug_ref
NCT06796517