drug_type
RELEVANT_DRUG
intervention_type
Antibody-Drug Conjugate
drug_description
Monoclonal antibody linked to a cytotoxic payload to deliver chemotherapy directly to antigen-positive B cells.
nci_thesaurus_concept_id
C129823
nci_thesaurus_definition
Any tumor-targeting antibody conjugated to a cytotoxic agent that exerts an antineoplastic effect.
drug_mesh_term
Immunoconjugates
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
A monoclonal antibody targets an antigen on malignant B cells, is internalized, and releases a linked cytotoxic payload inside the cell, causing targeted chemotherapy-induced cell death (e.g., microtubule or DNA damage) in antigen-positive B cells; may also retain Fc-mediated effector functions.
drug_name
Antibody-drug conjugate
nct_id_drug_ref
NCT06796517