drug_type
RELEVANT_DRUG
intervention_type
CAR-T cellular therapy
drug_description
Autologous anti-BCMA CAR-T cell therapy (lentiviral-transduced T cells) that binds BCMA on malignant plasma cells/mature B cells and activates T-cell–mediated cytotoxicity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Ciltacabtagene Autoleucel
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells are lentiviral-transduced to express a chimeric antigen receptor that targets BCMA on malignant plasma cells/mature B cells; CAR engagement activates T‑cell signaling (CD3ζ with costimulation), leading to targeted cytotoxicity and elimination of BCMA-expressing cells.
drug_name
Ciltacabtagene autoleucel (cilta-cel)
nct_id_drug_ref
NCT06574126