drug_type
RELEVANT_DRUG
intervention_type
Drug (peptide-based immunotherapy)
drug_description
Intratumoral peptide-based immunotherapy designed to present immunogenic CMV/EBV viral peptides to recruit pre-existing virus-specific memory CD8+ T cells, inducing local cytotoxicity, inflammatory cytokines, dendritic cell activation, and epitope spreading to tumor antigens.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
PEPTIDE VACCINE
drug_class
Vaccine
drug_delivery_route
Intratumoral
drug_mechanism_of_action
Intratumoral administration of immunogenic CMV/EBV-derived peptides (HLA-A*0201–restricted) to present on tumor MHC-I, recruiting and activating pre-existing virus-specific memory CD8+ T cells. This triggers local cytotoxicity and inflammatory cytokines, activates dendritic cells, and drives cross-priming/epitope spreading to tumor antigens; designed to synergize with PD-1/PD-L1 blockade.
drug_name
Peptide Alarm Therapy (PAT)
nct_id_drug_ref
NCT05338658