drug_type
RELEVANT_DRUG
intervention_type
monoclonal antibody (biologic)
drug_description
Anti-CD52 monoclonal antibody used to deplete CD52-positive host lymphocytes to enhance CAR T-cell engraftment and persistence.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Anti-CD52 monoclonal antibody that binds CD52 on host lymphocytes and mediates immune cell depletion (via complement- and Fc-dependent cytotoxicity) to achieve lymphodepletion and enhance engraftment and persistence of allogeneic CAR T cells.
drug_name
ALLO-647
nct_id_drug_ref
NCT05714345