drug_type
RELEVANT_DRUG
intervention_type
Biologic
drug_description
Recombinant antibody-derived bispecific adapter protein that binds the RevCAR epitope on Allo-RevCAR01-T and CD123 on AML cells, bridging tumor and T cell to trigger CAR signaling; administered as continuous IV infusion.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Intravenous
drug_mechanism_of_action
Recombinant antibody‑derived bispecific adapter that simultaneously binds the RevCAR epitope on Allo‑RevCAR01‑T cells and CD123 on AML cells, bridging T cells and tumor cells to trigger CAR signaling and T‑cell cytotoxicity; enables dose‑tunable, reversible engagement via continuous infusion.
drug_name
R-TM123
nct_id_drug_ref
NCT05949125