drug_type
RELEVANT_DRUG
intervention_type
Biological (monoclonal antibody fragment)
drug_description
A monoclonal antibody Fab fragment that specifically binds and inhibits carbonic anhydrase XII (CA XII) on glioblastoma cells; used as the targeting moiety for radioimmunotherapy when labeled with lutetium-177.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibody Fragments
drug_category
RADIOIMMUNOCONJUGATE
drug_class
Conjugate
drug_delivery_route
Intracavitary
drug_mechanism_of_action
A monoclonal antibody Fab fragment that binds carbonic anhydrase XII (CA XII) on glioblastoma cells and, when labeled with lutetium-177, delivers targeted beta radiation to induce localized DNA damage and tumor cell death; CA XII binding may also inhibit its enzymatic activity and disrupt tumor pH regulation.
drug_name
6A10 Fab (anti–carbonic anhydrase XII antibody fragment)
nct_id_drug_ref
NCT05533242