drug_type
RELEVANT_DRUG
intervention_type
Radiopharmaceutical
drug_description
A beta-emitting therapeutic radionuclide used to deliver localized radiation; in this trial it is conjugated to the 6A10 Fab to form a radiolabeled antibody (Lu-177–6A10 Fab) for intracavitary radioimmunotherapy.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Lutetium Radioisotopes
drug_category
RADIOIMMUNOCONJUGATE
drug_class
Conjugate
drug_delivery_route
Intracavitary
drug_mechanism_of_action
Lu-177–6A10 Fab binds carbonic anhydrase XII on glioblastoma cells and delivers localized beta radiation from lutetium-177, producing DNA damage and tumor cell kill near the resection cavity; the antibody fragment targets the isotope to CA XII–expressing tumor tissue, with gamma emissions enabling imaging/dosimetry.
drug_name
Lutetium-177
nct_id_drug_ref
NCT05533242