drug_type
RELEVANT_DRUG
intervention_type
Monoclonal antibody
drug_description
A humanized IgG monoclonal antibody given IV every 2 weeks that binds tumor-expressed CD24 to block the CD24–Siglec‑10 innate immune checkpoint, enhancing macrophage-mediated phagocytosis and potentially engaging Fc-dependent effector functions (ADCC/ADCP) in adults with advanced solid tumors.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Monoclonal, Humanized
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Humanized IgG monoclonal antibody that binds CD24 on tumor cells to block the CD24–Siglec‑10 innate immune checkpoint, enhancing macrophage-mediated phagocytosis and potentially engaging Fc-dependent effector functions (ADCC/ADCP).
drug_name
IMM47
nct_id_drug_ref
NCT05985083