drug_type
RELEVANT_DRUG
intervention_type
Monoclonal antibody
drug_description
A fully human IgG1κ monoclonal antibody that binds the conserved AD-2 site I epitope on HCMV glycoprotein B (gB), neutralizing virus by blocking gB-mediated attachment/fusion and cell-to-cell spread, and engaging Fc-mediated effector functions (ADCC and complement).
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Monoclonal
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Fully human IgG1κ monoclonal antibody that binds the conserved AD‑2 site I epitope on HCMV glycoprotein B (gB), neutralizing virus by blocking gB‑mediated attachment/fusion and cell‑to‑cell spread, while engaging Fc‑mediated effector functions (ADCC and complement) to enhance clearance.
drug_name
TRL345
nct_id_drug_ref
NCT05408091