drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR-NKT)
drug_description
Engineered natural killer T cells expressing a chimeric antigen receptor targeting CD70; designed to recognize and kill CD70-positive tumor cells via perforin/granzyme-mediated cytotoxicity and cytokine-driven immune activation, with potential tumor microenvironment remodeling.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
OTHER ENGINEERED IMMUNE CELL
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Engineered natural killer T (NKT) cells expressing a CD70-targeted chimeric antigen receptor bind CD70 on tumor cells, triggering CAR-mediated activation that induces perforin/granzyme-dependent cytotoxic killing and cytokine-driven immune activation, with potential remodeling of the tumor microenvironment.
drug_name
CGC729 (CD70-directed CAR-NKT cells)
nct_id_drug_ref
NCT06182735