drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy
drug_description
Universal chimeric natural killer receptor–modified T cells engineered to dual-target NKG2D and NKp44 (NCR2) ligands on tumors, triggering T-cell cytotoxicity and cytokine release.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Immunotherapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
T cells engineered with NK receptor–based chimeric receptors that dual-target ligands for NKG2D and NKp44 (NCR2) on tumor cells; ligand engagement triggers T‑cell activation signaling to drive cytotoxic killing and cytokine release, addressing antigen heterogeneity in solid tumors.
drug_name
CNK-UT
nct_id_drug_ref
NCT05976906