drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
A humanized anti-CD2 monoclonal antibody that binds CD2 on T lymphocytes and NK cells, leading to depletion/modulation of these cells and blockade of CD2–CD58 costimulatory/adhesion signaling to reduce autoreactive T-cell activation.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Siplizumab
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Humanized anti-CD2 monoclonal antibody that binds CD2 on T lymphocytes and NK cells, depleting/modulating these cells and blocking CD2–CD58 costimulatory/adhesion signaling to reduce autoreactive T-cell activation.
drug_name
TCD601 (siplizumab)
nct_id_drug_ref
NCT06025110