drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy
drug_description
Autologous T cells genetically engineered to express chimeric antigen receptors that recognize tumor antigens and activate T cells via CD3 signaling to kill malignant cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells are engineered to express a chimeric antigen receptor that binds tumor-associated antigens independent of MHC and activates T-cell signaling (CD3ΞΆ with costimulatory domains such as CD28 or 4-1BB), leading to proliferation and targeted cytotoxic killing of malignant cells via perforin/granzyme release and cytokine-mediated immune activation.
drug_name
CAR-T cell therapy
nct_id_drug_ref
NCT06377059