drug_type
RELEVANT_DRUG
intervention_type
Biologic antibody
drug_description
Bispecific monoclonal antibodies that bind a tumor-associated antigen and CD3 on T cells to redirect cytotoxic T-cell activity against malignant cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Bispecific
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Intravenous
drug_mechanism_of_action
Bispecific monoclonal antibodies that simultaneously bind CD3 on T cells and a tumor-associated antigen on malignant cells, crosslinking T cells to tumor targets to trigger CD3-mediated activation, immunologic synapse formation, and perforin/granzyme-mediated cytotoxic killing.
drug_name
T-cell–engaging bispecific antibodies
nct_id_drug_ref
NCT06377059