drug_type
RELEVANT_DRUG
intervention_type
Biologic (monoclonal antibody); administered via prefilled syringe or autoinjector
drug_description
Humanized IgG1 monoclonal antibody targeting OX40 (CD134); inhibits the OX40–OX40L T‑cell costimulatory pathway and depletes OX40+ activated T cells via Fc‑enhanced ADCC, reducing pathogenic effector/memory T‑cell activity and type 2 inflammatory cytokine signaling.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Subcutaneous
drug_mechanism_of_action
Humanized IgG1 monoclonal antibody against OX40 (CD134) that blocks OX40–OX40L costimulatory signaling and depletes OX40+ activated T cells via Fc-enhanced ADCC, reducing pathogenic effector/memory T-cell activity and type 2 inflammatory cytokine signaling.
drug_name
Rocatinlimab (AMG 451)
nct_id_drug_ref
NCT06224192