drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR T cells)
drug_description
Autologous T lymphocytes genetically engineered to express a chimeric antigen receptor targeting CD70; binding to CD70 on tumor cells triggers T-cell activation, cytokine release, and cytotoxic killing.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous, Intraperitoneal
drug_mechanism_of_action
Autologous T cells engineered to express a chimeric antigen receptor recognizing CD70. CAR engagement of CD70 on tumor cells triggers CD3ζ/co-stimulatory signaling, leading to T‑cell activation, expansion, cytokine release, and perforin/granzyme‑mediated cytotoxic killing of CD70‑expressing cancer cells.
drug_name
CD70 CAR-T cells
nct_id_drug_ref
NCT06215950