drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
Cytokine immunotherapy that activates TNFR1/TNFR2 on tumor and tumor-associated endothelial cells to induce apoptosis/necrosis, disrupt tumor vasculature, increase vascular permeability, and enhance local immune responses.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Tumor Necrosis Factor-alpha
drug_category
SIGNALING PROTEIN
drug_class
General immune activator
drug_delivery_route
Intraperitoneal
drug_mechanism_of_action
Recombinant modified human TNF-alpha cytokine that binds TNFR1/TNFR2 on tumor cells and tumor-associated endothelial cells, inducing apoptotic/necrotic signaling, disrupting tumor vasculature and increasing vascular permeability, and enhancing local antitumor immune responses.
drug_name
rmhTNF (recombinant modified human TNF-α)
nct_id_drug_ref
NCT05755685