drug_type
RELEVANT_DRUG
intervention_type
Biological (antibody–drug conjugate)
drug_description
An antibody–drug conjugate consisting of a humanized monoclonal antibody targeting folate receptor alpha (FOLRα) that, upon internalization into FOLRα-positive tumor cells, releases a cleavable cytotoxic payload that inhibits microtubules/tubulin, leading to mitotic arrest and apoptosis.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Humanized anti-FOLRα monoclonal antibody binds FOLRα on tumor cells, is internalized, and releases a cleavable microtubule/tubulin-inhibiting cytotoxic payload, causing mitotic arrest and apoptosis in FOLRα-positive cancer cells.
drug_name
STRO-002 (luveltamab tazevibulin)
nct_id_drug_ref
NCT06238687