drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
HER2-targeted antibody–drug conjugate composed of trastuzumab linked to the microtubule inhibitor DM1, delivering cytotoxic payload to HER2-overexpressing tumor cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Trastuzumab emtansine
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
HER2-targeted trastuzumab linked to the microtubule inhibitor DM1. Binds HER2 to inhibit signaling and mediate ADCC, is internalized into HER2-overexpressing tumor cells, then releases DM1 to disrupt microtubules, causing mitotic arrest and apoptosis.
drug_name
Ado-trastuzumab emtansine (T-DM1)
nct_id_drug_ref
NCT06446882