drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
An antibody–drug conjugate targeting HER2 that is internalized after binding, releasing the cytotoxic payload MMAE to disrupt microtubules and induce tumor cell apoptosis (with potential bystander effect).
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
disitamab vedotin
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Anti‑HER2 monoclonal antibody linked to MMAE. After binding HER2 on tumor cells, the ADC is internalized and releases MMAE, which disrupts microtubules (tubulin polymerization inhibition), causing cell-cycle arrest and apoptosis, with potential bystander killing of adjacent cells.
drug_name
Disitamab Vedotin (RC48)
nct_id_drug_ref
NCT05726175