drug_type
RELEVANT_DRUG
intervention_type
Cell therapy (CAR T)
drug_description
Autologous T cells engineered via lentiviral vector to express a second-generation CD7-targeted CAR with 4-1BB costimulation and CD3 signaling; manufactured from CD7− T cells to prevent fratricide; mediates recognition and killing of CD7+ tumor cells with enhanced persistence/expansion.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells engineered via lentiviral vector to express a second-generation CD7-targeted CAR with CD3z signaling and 4-1BB costimulation, manufactured from CD7− T cells to prevent fratricide. Upon binding CD7 on tumor cells, the CAR activates the T cells to proliferate and mediate cytotoxic killing of CD7+ malignant cells, with 4-1BB enhancing persistence and expansion.
drug_name
CD7-specific CAR-T cells
nct_id_drug_ref
NCT06720324