drug_type
RELEVANT_DRUG
intervention_type
Antibody-drug conjugate (HER2-targeted)
drug_description
HER2-targeted antibody-drug conjugate that binds HER2 (including low-expressing tumors), is internalized, and releases the microtubule inhibitor MMAE (monomethyl auristatin E) to induce cancer cell apoptosis.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
HER2-targeted monoclonal antibody linked to monomethyl auristatin E (MMAE). After binding HER2 on tumor cells (including low expressers), the ADC is internalized and cleaved to release MMAE, which inhibits tubulin polymerization, causing G2/M arrest and apoptosis; the membrane-permeable payload can also exert a bystander cytotoxic effect.
drug_name
Disitamab Vedotin (RC48-ADC)
nct_id_drug_ref
NCT06227117