drug_type
RELEVANT_DRUG
intervention_type
Biologic antibody therapy
drug_description
Bispecific IgG antibodies that bind CD3 on T cells and a lymphoma-associated antigen to form an immune synapse, activating T cells to kill tumor cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Bispecific
drug_category
BISPECIFIC T ENGAGER
drug_class
Engager
drug_delivery_route
Intravenous
drug_mechanism_of_action
Bispecific IgG antibodies that simultaneously bind CD3 on T cells and a lymphoma-associated antigen on tumor cells, physically bridging the cells to form an immune synapse. This triggers TCR/CD3 signaling, T-cell activation and cytokine release, leading to perforin/granzyme-mediated, MHC-independent lysis of the target tumor cell and serial killing.
drug_name
Bispecific T-cell–engager antibodies
nct_id_drug_ref
NCT06202885