drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
An anti-HER2 antibody–drug conjugate that delivers the microtubule inhibitor MMAE to HER2-expressing tumor cells, causing mitotic arrest and apoptosis, and mediating ADCC.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Disitamab Vedotin
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Disitamab vedotin is an anti-HER2 antibody–drug conjugate that binds HER2 on tumor cells, is internalized, and releases the cytotoxic payload MMAE via a cleavable linker. MMAE inhibits tubulin polymerization, causing mitotic arrest and apoptosis. The antibody component can also mediate ADCC.
drug_name
Disitamab Vedotin (RC48, DV)
nct_id_drug_ref
NCT06221748