drug_type
RELEVANT_DRUG
intervention_type
Cell therapy (autologous T cells)
drug_description
Autologous adoptive T-cell therapy expanded from tumor-associated lymph nodes; tumor-reactive T cells that recognize tumor antigens via TCRs and mediate cytotoxicity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
TCR SELECTED T CELLS
drug_class
Unedited cells
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells expanded from tumor-associated lymph nodes that retain native TCRs specific for tumor antigens. After infusion, they recognize peptide–MHC on tumor cells via their endogenous TCRs and mediate antitumor activity through cytotoxic granule release and cytokine secretion.
drug_name
Tumor-associated lymph node T cells (TAL-T)
nct_id_drug_ref
NCT06302062